Gabica (Pregabalin) is an analogue of the neurotransmitter gamma-aminobutyric acid (GABA).
It has analgesic and anticonvulsant activity.
Pregabalin reduces neuronal calcium currents by binding to the alpha-2-delta subunit of voltage gated calcium channels in the CNS tissues and this particular mechanism maybe responsible for effects in neuropathic pain, anxiety and other syndromes.
It is inactive at serotonin and dopamine receptors and does not inhibit dopamine, serotonin, or noradrenaline reuptake.
Gabica is indicated for the management of neuropathic pain associated with diabetic peripheral neuropathy, management of postherpetic neuralgia, treatment of fibromyalgia syndrome and as an adjunctive therapy in adults with partial seizures with or without secondary generalization.
HOW TO USE
Gabica is given orally with or without food.
The recommended dose of Gabica is 75 to 150 mg per day, given as 2-3 divided doses.
Pregabalin is contraindicated in patients with a known hypersensitivity to pregabalin or any of its components.
Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.